

Medistem Laboratories Inc., the company whose researchers published the recent stem cell treatment proposal in the Journal of Translational Medicine has applied for a patent in respect of its stem cell therapy which covers patient selection, therapeutic combinations and various stem cell types. Hopefully the patent, if granted, promotes further research and development in this area, and if the treatment is proven effective and beneficial to autistic patients, does not render the price of treatment beyond reach for generations.
Medistem Announces Autism Stem Cell Therapy Paper and Filing of IP Aug 1 2007, 5:05 AM EST MARKETWIRE Aug 01, 2007 SCOTTSDALE, AZ MARKET WIRE Medistem Laboratories, Inc. (OTCBB: MDSM) (FRANKFURT: S2U) announced today the filing of IP and publication of a peer reviewed paper describing a novel method of selecting specific subsets of autistic patients for treatment with a combination of cellular therapies. "Based on positive case report data from one of our licensees, Medistem plans to explore the possibility of seeking regulatory approval in the U.S. for a Phase I clinical trial involving our novel stem cell therapeutic methods for treatment of autism," said Neil Riordan PhD, President and CEO of Medistem. He continued, "We are at the stage where a patent application has been filed, we've announced the scientific basis for our program in a peer reviewed journal, and now we are seeking and initiating discussions with clinical collaborators and patient interest groups in the U.S." Medistem published a paper entitled "Stem Cell Therapy for Autism" in the Journal of Translational Medicine that is freely available online at http://www.translational-medicine.com/content/pdf/1479-5876-5-30.pdf. A video summary of the paper may be seen at http://www.youtube.com/watch?v=FlSaXCzLW6w Thomas Ichim, Medistem's Chief of Scientific Development and primary author on the paper, stated, "Given the staggering incidence of autism in the U.S. (approximately 1 in 166), and the lack of viable treatment options, we believe that our IP in this area will not only allow for internal product development, but also enable Medistem to seek collaboration with other companies that have approval for using stem cells in the U.S. under clinical trial exemptions." Medistem has numerous patent applications filed in the area of stem cell expansion, composition of matter, and therapeutic use. The patent application entitled "Stem Cell Therapy for Autism" covers patient selection, therapeutic combinations, and various stem cell types for the treatment of autism. About Medistem Laboratories, Inc. Medistem Laboratories is a biotechnology company that discovers, develops, and commercializes adult stem cell products that address serious medical conditions. While drug discovery and development is its primary focus, Medistem has compiled a body of proprietary technologies it outlicenses to commercial entities in markets where stem cell administration is permissible. Due to its licensee relationships and collaborative efforts with respected institutions, Medistem believes it is well positioned to be a leading developer of adult stem cell products. Cautionary Statement This document does not constitute an offer to sell or a solicitation of an offer to buy any of our securities. This document contains certain forward-looking statements within the meaning of Section 27A of the Securities Act of 1933, as amended, and Section 21E of the Securities Exchange Act of 1934, as amended. These forward-looking statements may include projections of matters that affect revenue, the ability to develop or license certain technologies; operating expenses or net earnings; projections of capital expenditures; projections of growth; hiring plans; plans for future operations; financing needs or plans; plans relating to the company's products and services; and assumptions relating to the foregoing. Forward-looking statements are inherently subject to risks and uncertainties, some of which cannot be predicted or quantified. Future events and actual results could differ materially from those set forth in, contemplated by, or underlying the forward-looking information. Some of the important factors that could cause the company's actual results to differ materially from those projected in forward-looking statements made by the company include, but are not limited to, the following: technology development limitations, intense competition, risk of business interruption, management of rapid growth, need for additional financing, regulatory approvals and requirements, dependence on key personnel and research, management and other administrative costs. These factors are discussed in greater detail in the company's quarterly and annual periodic reports, all as filed with the Securities and Exchange Commission. Contact: Medistem Laboratories, Inc. Chris McGuinn 602-318-3535 http://www.medisteminc.com
http://www.genengnews.com/news/bnitem.aspx?name=21104666 SOURCE: Medistem Laboratories
Wednesday, August 01, 2007
Autism Stem Cell Therapy Patent Application Filed
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Labels: autism disorder, autism research, Medistem Laboratories Inc., patent application, stem cell autism treatment
Saturday, July 28, 2007
Stem Cell Autism Treatment Proposal



More fascinating developments in autism research are brought forward with publication of a peer reviewed open access article in the Journal of Translational Medicine 2007, 5:30. The authors propose the use of stem cells to treat autism. Translation Medicine refers to a field of medicine which attempts to convert research into actual treatment for patients, a joining of research and clinical practice of medicine. The proposal is premised on a consistent association of autism with immune abnormalities and neural hypoperfusion (decreased blood flow). The authors speculate that stem cells might be used to stimulate repair of neural damage.
Four of the authors are associated with the Institute of Cellular Medicine which indicates that it is now accepting some autistic patients for stem cell therapy:
Stem Cell Therapy is Available Now The Institute of Cellular Medicine (ICM) is currently accepting patients with the following conditions for stem cell therapy:
http://www.cellmedicine.com/
Stem Cell Therapy for Autism Thomas E Ichim1
, Fabio Solano2
, Eduardo Glenn2
, Frank Morales2
, Leonard Smith2
, George Zabrecky3
and Neil H Riordan1 ,4
1Medistem Laboratories Inc, Tempe, Arizona, USA 2Institute for Cellular Medicine, San Jose, Costa Rica 3Americas Medical Center, Ridgefield, Connecticut, USA 42027 E. Cedar Street Suite 102 Tempe, AZ 85281, USAJournal of Translational Medicine 2007, 5:30 doi:10.1186/1479-5876-5-30
Autistic disorder, or autism is the most common form of ASD. Although several neurophysiological alterations have been associated with autism, immune abnormalities and neural hypoperfusion appear to be broadly consistent. These appear to be causative since correlation of altered inflammatory responses, and hypoperfusion with symptology is reported. Mesenchymal stem cells (MSC) are in late phases of clinical development for treatment of graft versus host disease and Crohn's Disease, two conditions of immune dysregulation. Cord blood CD34+ cells are known to be potent angiogenic stimulators, having demonstrated positive effects in not only peripheral ischemia, but also in models of cerebral ischemia. Additionally, anecdotal clinical cases have reported responses in autistic children receiving cord blood CD34+ cells. We propose the combined use of MSC and cord blood CD34+cells may be useful in the treatment of autism.http://www.translational-medicine.com/content/5/1/30

http://www.translational-medicine.com/content/pdf/1479-5876-5-30.pdf
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Labels: autism disorder, Eduardo Glenn, Fabio Solano, Frank Morales, George Zabrecky, Leonard Smith, Neil H Riordan, stem cell autism treatment, Thomas E Ichim










